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1994-09-19
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Document 0372
DOCN M9490372
TI Potential for bias in studies of the influence of human immunodeficiency
virus infection on the recognition, incidence, clinical course, and
microbiology of pelvic inflammatory disease.
DT 9411
AU Irwin KL; Rice RJ; Sperling RS; O'Sullivan MJ; Brodman M; National
Center for Infectious Diseases, Centers for Disease; Control and
Prevention, Atlanta, Georgia.
SO Obstet Gynecol. 1994 Sep;84(3):463-9. Unique Identifier : AIDSLINE
MED/94336136
AB As the human immunodeficiency virus (HIV) epidemic affects more women,
clinicians are increasingly observing pelvic inflammatory disease (PID)
in HIV-infected women. The extent to which PID is a factor in the
recognition of HIV or HIV is a factor in the recognition of PID is
unknown. Even less is known about how HIV infection influences the
development, clinical course, and microbiology of PID. The paucity of
existing data largely results from difficulties in designing studies
that are free of bias. Several biases may distort studies of the effect
of HIV on the recognition, incidence, clinical presentation and course,
and microbiology of PID. Selection bias, diagnostic bias, and
confounding bias are the most likely causes of invalid conclusions in
studies of the influence of HIV infection on these aspects of PID, for
three major reasons: Factors that determine patients' health care
seeking behavior may be related to HIV status; the diagnosis of PID
tends to be imprecise; and extraneous factors that cause or prevent PID
may be distributed differently in HIV-infected and HIV-uninfected women.
Appropriate study design and analytic techniques can eliminate, reduce,
or estimate the magnitude and direction of these biases, thereby
yielding more valid conclusions. To interpret properly existing and
future studies of the influence of HIV infection on PID, clinicians must
consider several biases that may distort results.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY
Adnexitis/*EPIDEMIOLOGY/MICROBIOLOGY Bias (Epidemiology) Confounding
Factors (Epidemiology) Female Human HIV Infections/*EPIDEMIOLOGY HIV
Seronegativity HIV Seropositivity/EPIDEMIOLOGY Incidence Prevalence
Selection Bias Support, U.S. Gov't, P.H.S. United States/EPIDEMIOLOGY
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).